Biferno wines are produced in the province of Campobasso and include Italian wine, reds, whites and roses. The white blends comprise mainly Trebbiano Toscano supported by smaller portions of Bombino, while the reds lean towards Montepulciano combined with a little Aglianico and some Trebbiano Toscano. Pentro di Isernia also produces all three, although its red blend consists of a Montepulciano/Sangiovese mix. Biferno's wines differ slightly, displaying less acidity and more body because of its terroir: mountains give way to high plains that slope down towards the sea.
In 1998, these two DOCs were joined by the newer Molise del Molise DOC, which encompasses the whole region and (unlike its counterparts) also makes sparkling spumante. Several grape varieties reign in this area, including Aglianico, Cabernet Sauvignon, Chardonnay, Falanghina, Montepulciano and the native Tintilia.